DRREDDY

HYDERABAD, Jan 21 (Reuters) - Indian drugmaker Dr Reddy's REDY.NS reported a smaller-than-expected fall in quarterly profit on Wednesday on steady domestic demand.

The company's consolidated net profit fell 14.4% to 12.1 billion rupees ($132 million) in the quarter ended December 31. Analysts, on average, had estimated profit to fall to 10.70 billion rupees, as per data compiled by LSEG.

This is the drugmaker's first quarterly profit fall in five quarters.

($1 = 91.6650 Indian rupees)

(Reporting by Rishika Sadam and Kashish Tandon; Editing by Janane Venkatraman)

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Adds details on Roche, Abbvie and CSL

Jan 20 (Reuters) - Global drugmakers are ramping up U.S. manufacturing and stockpiling inventory as the Trump administration considers a 100% tariff on imported branded and patented medicines.

Although enforcement is delayed for companies investing in U.S. manufacturing, the policy has already prompted fast-tracked projects, price cuts and direct-to-consumer sales.

Pfizer and AstraZeneca secured multi-year tariff exemptions through pricing deals and commitments to the new TrumpRx.gov platform. Eli Lilly, Johnson & Johnson and Merck have pledged billions to expand U.S. operations to avoid penalties.

Here's what drugmakers are doing to mitigate supply-chain risks and reassure investors:

Pfizer PFE.N

Pfizer reached a deal with President Donald Trump on September 30 to invest $70 billion in research and development and domestic manufacturing, and received a three-year grace period exempting its products from the pharmaceutical-targeted tariffs.

GSK GSK.L

The London-based drugmaker plans to invest $30 billion in U.S. research and development and supply chain infrastructure over five years.

Eli Lilly LLY.N

The U.S. drugmaker said in September it will invest $5 billion to build a manufacturing facility in Virginia. The facility is the first of four new U.S. plants planned under its $27 billion expansion over the next five years.

Johnson & Johnson JNJ.N

The drugmaker plans to raise U.S. investments by 25%, totaling $55 billion, over the next four years. It plans to build four plants, including one at Wilson, North Carolina, and another at Tokyo-based Fujifilm Biotechnologies' manufacturing site in Holly Springs, North Carolina, over the next 10 years.

Locations for the other plants remain undisclosed.

Roche ROG.S

The Swiss drugmaker said in April last year it will invest $50 billion in the U.S. over the next five years.

A month later, it announced an additional $550 million investment to expand its Indianapolis diagnostics manufacturing hub. The expansion will span Indiana, Pennsylvania, Massachusetts, and California, creating more than 12,000 jobs.

In January, Roche said it will more than double its investment in its drug manufacturing facility in Holly Springs, North Carolina, to about $2 billion, up from the over $700 million announced in May 2025.

AstraZeneca AZN.L

The Anglo-Swedish drugmaker will invest $50 billion on U.S. manufacturing by 2030. The investment will fund a new drug substance facility in Virginia, its largest single-site global investment, alongside expansions in Maryland, Massachusetts, California, Indiana and Texas.

It has already started technology transfers and is managing inventory in 2025 to minimize any tariff hit. Company executives have said the impact would be "very short-lived."

Novartis NOVN.S

The Swiss drugmaker plans to spend $23 billion to build and expand 10 facilities in the U.S. over the next five years. This includes building six new manufacturing plants and expanding its San Diego research and development site, which is expected to create more than 1,000 jobs.

Sanofi SASY.PA

The French drugmaker plans to invest at least $20 billion in the U.S. through 2030 to boost manufacturing and research. Sanofi plans to expand its U.S. manufacturing capacity through direct investments in the company's sites and partnerships with other domestic manufacturers.

Chief Financial Officer François Roger said in July the potential tariffs are expected to have a limited impact in 2025, as the company already has inventory in place in the U.S.

Biogen BIIB.O

The U.S. drugmaker will invest $2 billion more in its existing manufacturing plants in North Carolina, adding capacity for gene-targeting therapies and automation. The company has seven factories in the state, with an eighth set to begin operations in late 2025.

Merck MRK.N

The U.S. drugmaker has begun building a $3 billion pharmaceutical manufacturing plant in Virginia as part of its over $70 billion investment to expand domestic manufacturing and research and development in the United States.

It will also invest $1 billion in a new Delaware plant to make biologics and cancer drug Keytruda, to boost U.S. production and potentially create over 4,500 jobs. It also opened a $1-billion facility at its North Carolina site in March.

Merck's animal health unit will invest $895 million to expand its Kansas manufacturing and R&D site, part of a broader $9 billion U.S. investment through 2028.

CEO Robert Davis in July flagged minimal impact from potential tariffs in 2025, and that the company remained well-positioned due to inventory management and moving of manufacturing to the U.S.

Amgen AMGN.O

The U.S.-based biopharma firm plans to invest $900 million to expand its Ohio manufacturing facility, bringing total investment in the state to $1.4 billion and adding 750 jobs. In December, the company committed $1 billion to build a second facility in Holly Springs, North Carolina.

Amgen said in September it is investing more than $600 million to build a new research and development center at its headquarters in Thousand Oaks, California.

The drugmaker announced it will invest $650 million to expand drug manufacturing at its facility in Juncos, Puerto Rico, a move expected to create nearly 750 jobs.

Novo Nordisk NOVOb.CO

The Danish pharmaceutical company said in August its strong U.S. manufacturing footprint positions it well for tariff challenges, describing itself as "very U.S.-centric and U.S.-focused".

AbbVie ABBV.N

U.S. drugmaker AbbVie ABBV.N said in January it has committed $100 billion over the next decade to U.S.-based research and development as part of its three-year deal with the Trump administration to reduce drug prices.

It has 11 manufacturing sites in the U.S. and has said it is "fairly insulated" from any tariff impact this year given inventory management actions.

Gilead Sciences GILD.O

Earlier this year, the drugmaker announced $11 billion in new planned investment in the U.S. to add to its domestic manufacturing and research heft, taking its total pledged investment to $32 billion.

Gilead said in September that it started work on a pharmaceutical development and manufacturing hub at its headquarters in Foster City, California, in addition to which, it is currently developing two other sites.

Cipla CIPL.NS

The Indian drugmaker is expanding its U.S. manufacturing footprint by investing in capacity expansion for complex respiratory products at its advanced facilities in Fall River, Massachusetts, and Central Islip, Long Island, New York.

CSL CSL.AX

Australia's CSL said in November it would invest $1.5 billion in the U.S. to manufacture plasma-derived therapies, expanding its footprint in the country over the next five years.

(Reporting by Siddhi Mahatole, Kamal Choudhury, Puyaan Singh, Sneha S K and Sahil Pandey in Bengaluru; Editing by Maju Samuel, Tasim Zahid and Sahal Muhammed)

(([email protected];))

Jan 14 (Reuters) - Dr Reddy's Laboratories Ltd REDY.NS:

• DR REDDY'S - ANNOUNCES FIRST-TO-MARKET LAUNCH OF OLOPATADINE HYDROCHLORIDE OPHTHALMIC SOLUTION USP, 0.7%

• DR REDDY'S - FIRST-TO-MARKET LAUNCH OF OLOPATADINE HYDROCHLORIDE OPHTHALMIC SOLUTION IN U.S.

• DR REDDY'S - LAUNCHES OLOPATADINE SOLUTION IN U.S. MARKET

Source text: ID:nBSE6Ls2Xb

Further company coverage: REDY.NS

(([email protected];))

Changes dateline, paragraph 1 and updates AbbVie

Jan 13 (Reuters) - Global drugmakers are ramping up U.S. manufacturing and stockpiling inventory as the Trump administration considers imposing a 100% tariff on imported branded and patented medicines.

Although enforcement is delayed for companies investing in U.S. manufacturing, the policy has already prompted fast-tracked projects, price cuts and direct-to-consumer sales.

Pfizer and AstraZeneca secured multi-year tariff exemptions through pricing deals and commitments to the new TrumpRx.gov platform. Eli Lilly, Johnson & Johnson and Merck have pledged billions to expand U.S. operations to avoid penalties.

Here's what drugmakers are doing to mitigate supply-chain risks and reassure investors:

Pfizer PFE.N

Pfizer reached a deal with President Donald Trump on September 30 to invest $70 billion in research and development and domestic manufacturing, and received a three-year grace period exempting its products from the pharmaceutical-targeted tariffs.

GSK GSK.L

The London-based drugmaker plans to invest $30 billion in U.S. research and development and supply chain infrastructure over five years.

Eli Lilly LLY.N

The U.S. drugmaker said in September it will invest $5 billion to build a manufacturing facility in Virginia. The facility is the first of four new U.S. plants planned under its $27 billion expansion over the next five years.

Johnson & Johnson JNJ.N

The drugmaker plans to raise U.S. investments by 25%, totaling $55 billion, over the next four years. It plans to build four plants, including one at Wilson, North Carolina, and another at Tokyo-based Fujifilm Biotechnologies' manufacturing site in Holly Springs, North Carolina, over the next 10 years.

Locations for the other plants remain undisclosed.

Roche ROG.S

The Swiss drugmaker said in April it will invest $50 billion in the U.S. over the next five years.

A month later, it announced an additional $550 million investment to expand its Indianapolis diagnostics manufacturing hub. The expansion will span Indiana, Pennsylvania, Massachusetts, and California, creating more than 12,000 jobs.

Roche said in May it plans to invest more than $700 million in a new drug manufacturing facility in Holly Springs, North Carolina.

CEO Thomas Schinecker said in July the company had moved around inventories and ramped up production of all the medicines that it already produced in the U.S. in anticipation of tariffs.

AstraZeneca AZN.L

The Anglo-Swedish drugmaker will invest $50 billion on U.S. manufacturing by 2030. The investment will fund a new drug substance facility in Virginia, its largest single-site global investment, alongside expansions in Maryland, Massachusetts, California, Indiana and Texas.

It has already started technology transfers and is managing inventory in 2025 to minimize any tariff hit. Company executives have said the impact would be "very short-lived."

Novartis NOVN.S

The Swiss drugmaker plans to spend $23 billion to build and expand 10 facilities in the U.S. over the next five years. This includes building six new manufacturing plants and expanding its San Diego research and development site, which is expected to create more than 1,000 jobs.

Sanofi SASY.PA

The French drugmaker plans to invest at least $20 billion in the U.S. through 2030 to boost manufacturing and research. Sanofi plans to expand its U.S. manufacturing capacity through direct investments in the company's sites and partnerships with other domestic manufacturers.

Chief Financial Officer François Roger said in July the potential tariffs are expected to have a limited impact in 2025, as the company already has inventory in place in the U.S.

Biogen BIIB.O

The U.S. drugmaker will invest $2 billion more in its existing manufacturing plants in North Carolina, adding capacity for gene-targeting therapies and automation. The company has seven factories in the state, with an eighth set to begin operations in late 2025.

Merck MRK.N

The U.S. drugmaker has begun building a $3 billion pharmaceutical manufacturing plant in Virginia as part of its over $70 billion investment to expand domestic manufacturing and research and development in the United States.

It will also invest $1 billion in a new Delaware plant to make biologics and Keytruda, to boost U.S. production and potentially create over 4,500 jobs. It also opened a $1-billion facility at its North Carolina site in March.

Merck's animal health unit will invest $895 million to expand its Kansas manufacturing and R&D site, part of a broader $9 billion U.S. investment through 2028.

CEO Robert Davis in July flagged minimal impact from potential tariffs in 2025, and that the company remained well-positioned due to inventory management and moving of manufacturing to the U.S.

Amgen AMGN.O

The U.S.-based biopharma firm plans to invest $900 million to expand its Ohio manufacturing facility, bringing total investment in the state to $1.4 billion and adding 750 jobs. In December, the company committed $1 billion to build a second facility in Holly Springs, North Carolina.

Amgen said in September it is investing more than $600 million to build a new research and development center at its headquarters in Thousand Oaks, California.

The drugmaker announced it will invest $650 million to expand drug manufacturing at its facility in Juncos, Puerto Rico, a move expected to create nearly 750 jobs.

Novo Nordisk NOVOb.CO

The Danish pharmaceutical company said in August its strong U.S. manufacturing footprint positions it well for tariff challenges, describing itself as "very U.S.-centric and U.S.-focused".

AbbVie ABBV.N

U.S. drugmaker AbbVie ABBV.N has committed $100 billion over the next decade to U.S.-based research and development, expanding direct-to-patient access through TrumpRx for widely prescribed medications including Alphagan, Combigan, Humira, and Synthroid

In exchange, AbbVie will receive exemptions from tariffs and future pricing mandates, though additional terms of the agreement with the Trump's administration remain confidential.

Before this, AbbVie confirmed plans to continue investing in its previously announced $10 billion expansion in the country over the next decade.

It already has 11 manufacturing sites in the U.S. and has said it is "fairly insulated" from any tariff impact this year given inventory management actions.

Gilead Sciences GILD.O

Earlier this year, the drugmaker announced $11 billion in new planned investment in the U.S. to add to its domestic manufacturing and research heft, taking its total pledged investment to $32 billion.

Gilead said in September that it started work on a pharmaceutical development and manufacturing hub at its headquarters in Foster City, California, in addition to which, it is currently developing two other sites.

Cipla CIPL.NS

The Indian drugmaker is expanding its U.S. manufacturing footprint by investing in capacity expansion for complex respiratory products at its advanced facilities in Fall River, Massachusetts, and Central Islip, Long Island, New York.

CSL CSL.AX

Australia's CSL said it would invest $1.5 billion in the U.S. to manufacture plasma-derived therapies, expanding its footprint in the North American country over the next five years.

(Reporting by Siddhi Mahatole, Kamal Choudhury, Puyaan Singh and Sneha S K in Bengaluru; Editing by Devika Syamnath, Leroy Leo, Vijay Kishore, Sahal Muhammed, Maju Samuel and Tasim Zahid)

(([email protected];))

The author is a Reuters Breakingviews columnist. The opinions expressed are her own. Refiles to change editing credits.

By Shrabani Chakraborty

BENGALURU, Jan 9 (Reuters Breakingviews) - Novo Nordisk NOVOb.CO is fuelling an obesity drug war in India. Last month, the $229 billion Danish drugmaker launched its blockbuster remedy Ozempic into the world’s fifth-largest economy. The once-weekly jab costs a mere 8,800 rupees ($97.94) per month, a staggering discount compared to the U.S. where the same prescription can cost nearly $500. Competition from arch rival Eli Lilly LLY.N and a looming patent cliff will play out on a larger scale in the U.S. in the coming years.

India's obesity levels are rising sharply. In the past three decades, urbanisation encouraged more sedentary lifestyles and diets have shifted towards ultra-processed foods. By 2022, about 24% of India’s population was classified as either overweight or obese, and the situation is expected to get worse. Last year, Prime Minister Narendra Modi described obesity as a “silent crisis” and reckoned that it could affect nearly 440 million Indians by 2050, or around a third of today's 1.4 billion population. To tackle the problem, he urged families to cut 10% of cooking oil use and adopt regular exercise.

This healthcare dilemma, however, has created an opportunity for obesity drug giants. In the past year, Eli Lilly and Novo Nordisk have launched Mounjaro and Wegovy, respectively, in the Indian market. But a price war escalated quickly. In March 2025, Mounjaro began selling its injectable drug at 14,000–17,500 rupees per month. Novo Nordisk then followed with Wegovy in June at 10,850 rupees per month. As these drugs gained popularity, Ozempic debuted in December 2025 at 8,800 rupees per month, positioning itself as the most affordable option in India.

This pricing strategy is about fending off competition from all angles. Generic drugmakers like Dr. Reddy's REDY.NS and Sun Pharma SUN.NS are scrambling to develop copycat versions of Novo's drugs once the key patent expires in March 2026. But if the Danish group’s drugs are also ultra cheap, the generic rivals are unlikely to take much market share.

Novo may need to adopt a similar strategy in the U.S. In 2031, the patent on the key ingredient in Ozempic and Wegovy will expire, which is likely to trigger intense competition from generic drugmakers. According to Visible Alpha data, Novo Nordisk's revenue will dip 0.33% in 2032 and 1.95% in 2033. But if an India-style price war breaks out, the sales decline may be much more dramatic. Investors have good reason to use India’s weight-loss drug showdown as a warning, not an outlier.

Follow Shrabani Chakraborty on X and LinkedIn.

CONTEXT NEWS

Novo Nordisk launched Ozempic in India on December 12, pricing the 0.25 mg dose at $24.35 per week.

Ozempic will be sold in pen format in 0.25 mg, 0.5 mg and 1 mg doses, with each pen covering four weekly doses.

Monthly prices are 8,800 rupees for 0.25 mg, 10,170 rupees for 0.5 mg and 11,175 rupees for 1 mg doses.

(Editing by Aimee Donnellan; Production by Aditya Srivastav)

(([email protected]))

Jan 8 (Reuters) - The U.S. Supreme Court is set to issue rulings on Friday on cases related to the legality of tariffs imposed by President Donald Trump under the International Emergency Economic Powers Act.

The administration faces the possibility of having to refund nearly $150 billion paid in tariffs to importers if the court declares that the sweeping duties Trump has imposed under the IEEPA are illegal.

Major corporations such as Costco COST.O, Revlon, Ray-Ban eyeglass maker EssilorLuxottica ESLX.PA, Bumble Bee Foods, Yokohama Tire 5101.T and Kawasaki Motors 7012.T have sued the U.S. government challenging IEEPA-based tariffs and seeking refunds on duties paid.

The tariffs invoked under the Emergency act fall into three categories: fentanyl-linked tariffs on China, Mexico and Canada; broad "reciprocal" tariffs aimed at shrinking trade deficits; and punitive levies against countries for non-trade political reasons.

Notably, pharmaceuticals, energy, agricultural commodities, services as well as aircraft and aerospace industries have been largely exempt from U.S. tariffs, protected due to their critical nature, global supply chains and potential impact on public health and international commerce.

Meanwhile, the EU and countries such as the UK, Japan, South Korea, Vietnam and Switzerland have struck tariff-reduction deals with the U.S. in exchange for market access and investment commitments.

Here are some countries and industries exposed to the IEEPA-based tariffs:

(Reporting by Pooja Menon and Puyaan Singh in Bengaluru; Editing by Alan Barona)

(([email protected]))

Dec 31 (Reuters) - Dr Reddy's Laboratories Ltd REDY.NS:

• DR. REDDY'S LABORATORIES SA RECEIVES COMPLETE RESPONSE LETTER FROM USFDA

• LETTER REFERS TO INSPECTION OBSERVATIONS AT ALVOTECH FACILITY

• COMPLETE RESPONSE LETTER FOR BLA FOR AVT03 BIOSIMILAR TO PROLIA & XGEVA

Source text: ID:nNSEbhHnJd

Further company coverage: REDY.NS

(([email protected];))

Dec 8 (Reuters) - Immutep Ltd IMM.AX:

• IMMUTEP ENTERS INTO STRATEGIC COLLABORATION WITH DR. REDDY'S

• IMMUTEP TO RECEIVE UPFRONT PAYMENT OF USD 20 MILLION

• ELIGIBLE TO RECEIVE POTENTIAL REGULATORY DEVELOPMENT AND COMMERCIAL MILESTONE PAYMENTS OF UP TO USD 349.5 MILLION

Further company coverage: IMM.AX

(([email protected];))

Updates to add comment from Novo Nordisk in para 5, 6, 7

By Rishika Sadam

HYDERABAD, India, Dec 3 (Reuters) - Danish drugmaker Novo Nordisk NOVOb.CO will launch its blockbuster diabetes drug Ozempic in India this month, three sources familiar with the matter said, as it seeks to strengthen its foothold in the world's most populous nation.

India has the second-highest number of people with type 2 diabetes after China and rising obesity rates, making it a critical battleground for drugmakers vying for a share of the fast-growing weight-loss treatment market, which analysts expect to reach $150 billion annually by the end of the decade.

Ozempic, a once-weekly injectable approved by the U.S. Food and Drug Administration in 2017 for type 2 diabetes, has become a global bestseller and is widely used off-label for weight loss due to its appetite-suppressing effects. Novo's Wegovy, which like Ozempic is semaglutide, is approved for weight loss.

"Novo wants Ozempic in the market before generics bring out cheaper versions," one of the sources said, adding the launch could happen within the next three to four weeks.

Novo, which in September said it secured Indian regulatory approval to import and sell Ozempic, on Thursday said it hoped to launch the drug as early as possible, but did not give further details on an updated timeline or the drug's pricing.

"We understand that India is a price sensitive market and hence we are working hard towards pricing (Ozempic) that is market competitive," Novo Nordisk India Managing Director Vikrant Shrotriya told Reuters in an email.

Ozempic arrival in India will complete Novo's semaglutide portfolio offering treatment for diabetes and obesity in the country, he said.

The move comes as Wegovy faces stiff competition from U.S. rival Eli Lilly LLY.N, whose Mounjaro, which is approved for diabetes and weight loss, became India's top-selling drug by value in October, according to Pharmarack data.

LILLY HOLD LEAD, GENERICS ON THE HORIZON

Lilly sold 262,000 doses of Mounjaro in October, compared with 26,000 doses of Novo's Wegovy, which entered the market in June.

Last month, Novo cut Wegovy's price in India by up to 37% ahead of the March 2026 expiration of its patent on semaglutide, which will open the door to cheaper generics.

India's generic drugmakers including Sun Pharma SUN.NS, Cipla CIPL.NS, Dr Reddy's REDY.NS and Lupin LUPN.NS have been developing their own versions of semaglutide to get in on the weight-loss windfall.

Novo already has a strong foothold in India's diabetes market through its Rybelsus semaglutide tablets and other products, Systematix Institutional Equities analyst Vishal Manchanda said, adding that Novo will be better poised to push Ozempic because of its strong brand reputation in the diabetes therapy area.

"There is a possibility that Ozempic could be prescribed for those suffering with infertility, sleep apnea and looking to shed some weight," Manchanda said.

Ozempic, Wegovy and Mounjaro belong to a class of drugs known as GLP-1 agonists originally developed for diabetes, but which mimic a hormone that also slows digestion and helps people feel full longer.

(Reporting by Rishika Sadam; Editing by Dhanya Skariachan and Bill Berkrot)

(([email protected];))

By Rishika Sadam

HYDERABAD, India, Dec 3 (Reuters) - Danish drugmaker Novo Nordisk NOVOb.CO will launch its blockbuster diabetes drug Ozempic in India this month, three sources familiar with the matter said, as it seeks to strengthen its foothold in the world's most populous nation.

India has the second-highest number of people with type 2 diabetes after China and rising obesity rates, making it a critical battleground for drugmakers vying for a share of the fast-growing weight-loss treatment market, which analysts expect to reach $150 billion annually by the end of the decade.

Ozempic, a once-weekly injectable approved by the U.S. Food and Drug Administration in 2017 for type 2 diabetes, has become a global bestseller and is widely used off-label for weight loss due to its appetite-suppressing effects. Novo's Wegovy, which like Ozempic is semaglutide, is approved for weight loss.

"Novo wants Ozempic in the market before generics bring out cheaper versions," one of the sources said, adding the launch could happen within the next three to four weeks.

Novo in September said it secured Indian regulatory approval to import and sell Ozempic and hoped to launch as soon as possible, but did not immediately respond to requests for comment on an updated timeline or the drug's pricing.

The move comes as Wegovy faces stiff competition from U.S. rival Eli Lilly LLY.N, whose Mounjaro, which is approved for diabetes and weight loss, became India's top-selling drug by value in October, according to Pharmarack data.

LILLY HOLD LEAD, GENERICS ON THE HORIZON

Lilly sold 262,000 doses of Mounjaro in October, compared with 26,000 doses of Novo's Wegovy, which entered the market in June.

Last month, Novo cut Wegovy's price in India by up to 37% ahead of the March 2026 expiration of its patent on semaglutide, which will open the door to cheaper generics.

India's generic drugmakers including Sun Pharma SUN.NS, Cipla CIPL.NS, Dr Reddy's REDY.NS and Lupin LUPN.NS have been developing their own versions of semaglutide to get in on the weight-loss windfall.

Novo already has a strong foothold in India's diabetes market through its Rybelsus semaglutide tablets and other products, Systematix Institutional Equities analyst Vishal Manchanda said, adding that Novo will be better poised to push Ozempic because of its strong brand reputation in the diabetes therapy area.

"There is a possibility that Ozempic could be prescribed for those suffering with infertility, sleep apnea and looking to shed some weight," Manchanda said.

Ozempic, Wegovy and Mounjaro belong to a class of drugs known as GLP-1 agonists originally developed for diabetes, but which mimic a hormone that also slows digestion and helps people feel full longer.

(Reporting by Rishika Sadam; Editing by Dhanya Skariachan and Bill Berkrot)

(([email protected];))

Nov 27 (Reuters) - Algorae Pharmaceuticals Ltd 1AI.AX:

• SIGNS DISTRIBUTION AGREEMENT WITH DR. REDDY'S LABORATORIES

• AGREEMENT TO SUPPLY CHEMOTHERAPY MEDICINE CAPECITABINE INTO AUSTRALIAN MARKET

Further company coverage: 1AI.AX

(([email protected];))

Changes dateline, adds CSL in last paragraph

Nov 18 (Reuters) - Global drugmakers are rushing to boost U.S. manufacturing and inventory as the Trump administration weighs a 100% tariff on imported branded and patented drugs.

Although enforcement is delayed for companies investing in U.S. manufacturing, the policy has already prompted fast-tracked projects, price cuts and direct-to-consumer sales.

Pfizer and AstraZeneca secured multi-year tariff exemptions through pricing deals and commitments to the new TrumpRx.gov platform. Eli Lilly, Johnson & Johnson and Merck have pledged billions to expand U.S. operations to avoid penalties.

Here's what drugmakers are doing to mitigate supply-chain risks and reassure investors:

Pfizer PFE.N

Pfizer reached a deal with President Donald Trump on September 30 to invest $70 billion in research and development and domestic manufacturing, and received a three-year grace period exempting its products from the pharmaceutical-targeted tariffs.

GSK GSK.L

The London-based drugmaker plans to invest $30 billion in U.S. research and development and supply chain infrastructure over five years.

Eli Lilly LLY.N

The U.S. drugmaker said in September it will invest $5 billion to build a manufacturing facility in Virginia. The facility is the first of four new U.S. plants planned under its $27 billion expansion over the next five years.

Johnson & Johnson JNJ.N

The drugmaker plans to raise U.S. investments by 25%, totaling $55 billion, over the next four years. It plans to build four plants, including one at Wilson, North Carolina, and another at Tokyo-based Fujifilm Biotechnologies' manufacturing site in Holly Springs, North Carolina, over the next 10 years.

Locations for the other plants remain undisclosed.

Roche ROG.S

The Swiss drugmaker said in April it will invest $50 billion in the U.S. over the next five years.

A month later, it announced an additional $550 million investment to expand its Indianapolis diagnostics manufacturing hub. The expansion will span Indiana, Pennsylvania, Massachusetts, and California, creating more than 12,000 jobs.

Roche said in May it plans to invest more than $700 million in a new drug manufacturing facility in Holly Springs, North Carolina.

CEO Thomas Schinecker said in July the company had moved around inventories and ramped up production of all the medicines that it already produced in the U.S. in anticipation of tariffs.

AstraZeneca AZN.L

The Anglo-Swedish drugmaker will invest $50 billion on U.S. manufacturing by 2030. The investment will fund a new drug substance facility in Virginia, its largest single-site global investment, alongside expansions in Maryland, Massachusetts, California, Indiana and Texas.

It has already started technology transfers and is managing inventory in 2025 to minimize any tariff hit. Company executives have said the impact would be "very short-lived."

Novartis NOVN.S

The Swiss drugmaker plans to spend $23 billion to build and expand 10 facilities in the U.S. over the next five years. This includes building six new manufacturing plants and expanding its San Diego research and development site, which is expected to create more than 1,000 jobs.

Sanofi SASY.PA

The French drugmaker plans to invest at least $20 billion in the U.S. through 2030 to boost manufacturing and research. Sanofi plans to expand its U.S. manufacturing capacity through direct investments in the company's sites and partnerships with other domestic manufacturers.

Chief Financial Officer François Roger said in July the potential tariffs are expected to have a limited impact in 2025, as the company already has inventory in place in the U.S.

Biogen BIIB.O

The U.S. drugmaker will invest $2 billion more in its existing manufacturing plants in North Carolina, adding capacity for gene-targeting therapies and automation. The company has seven factories in the state, with an eighth set to begin operations in late 2025.

Merck MRK.N

The U.S. drugmaker has begun building a $3 billion pharmaceutical manufacturing plant in Virginia as part of its over $70 billion investment to expand domestic manufacturing and research and development in the United States.

It will also invest $1 billion in a new Delaware plant to make biologics and Keytruda, to boost U.S. production and potentially create over 4,500 jobs. It also opened a $1-billion facility at its North Carolina site in March.

Merck's animal health unit will invest $895 million to expand its Kansas manufacturing and R&D site, part of a broader $9 billion U.S. investment through 2028.

CEO Robert Davis in July flagged minimal impact from potential tariffs in 2025, and that the company remained well-positioned due to inventory management and moving of manufacturing to the U.S.

Amgen AMGN.O

The U.S.-based biopharma firm plans to invest $900 million to expand its Ohio manufacturing facility, bringing total investment in the state to $1.4 billion and adding 750 jobs. In December, the company committed $1 billion to build a second facility in Holly Springs, North Carolina.

Amgen said in September it is investing more than $600 million to build a new research and development center at its headquarters in Thousand Oaks, California.

The drugmaker announced it will invest $650 million to expand drug manufacturing at its facility in Juncos, Puerto Rico, a move expected to create nearly 750 jobs.

Novo Nordisk NOVOb.CO

The Danish pharmaceutical company said in August its strong U.S. manufacturing footprint positions it well for tariff challenges, describing itself as "very U.S.-centric and U.S.-focused".

AbbVie ABBV.N

The U.S. drugmaker has confirmed plans to continue investing in its previously announced $10 billion expansion in the country over the next decade.

It already has 11 manufacturing sites in the U.S. and has said it is "fairly insulated" from any tariff impact this year given inventory management actions.

Gilead Sciences GILD.O

Earlier this year, the drugmaker announced $11 billion in new planned investment in the U.S. to add to its domestic manufacturing and research heft, taking its total pledged investment to $32 billion.

Gilead said in September that it started work on a pharmaceutical development and manufacturing hub at its headquarters in Foster City, California, in addition to which, it is currently developing two other sites.

Cipla CIPL.NS

The Indian drugmaker is expanding its U.S. manufacturing footprint by investing in capacity expansion for complex respiratory products at its advanced facilities in Fall River, Massachusetts, and Central Islip, Long Island, New York.

CSL CSL.AX

Australia's CSL said it would invest $1.5 billion in the U.S. to manufacture plasma-derived therapies, expanding its footprint in the North American country over the next five years.

(Reporting by Siddhi Mahatole, Kamal Choudhury, Puyaan Singh and Sneha S K in Bengaluru; Editing by Devika Syamnath, Leroy Leo, Vijay Kishore, Sahal Muhammed and Maju Samuel)

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Oct 24 (Reuters) - Dr Reddy's Laboratories Ltd REDY.NS:

• DR REDDY'S - SANJAY SHARMA ASSIGNED CHRO RESPONSIBILITIES EFFECTIVE DECEMBER 1, 2025

Source text: ID:nBSE3SLl7z

Further company coverage: REDY.NS

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Updates with Amgen's investment plan

Sept 26 (Reuters) - Global drugmakers are scrambling to shore up their U.S. manufacturing capacity and domestic inventory as the Trump administration weighs hefty tariffs on pharmaceutical imports into the country.

Companies with more exposure to the UK, the EU, South Korea, and Japan are likely in a better position, as these countries have secured favorable agreements that cap tariffs at around 15%.

However, with many countries still engaged in trade talks with the U.S., businesses worldwide are hedging their decisions pending further clarity on final tariff rates.

Here's what drugmakers are doing to mitigate supply-chain risks and reassure investors:

GSK GSK.L

The London-based drugmaker plans to invest $30 billion in U.S. research and development and supply chain infrastructure over five years.

Eli Lilly LLY.N

The U.S. drugmaker said in September it will invest $5 billion to build a manufacturing facility in Virginia. The facility is the first of four new U.S. plants planned under its $27 billion expansion over the next five years.

Johnson & Johnson JNJ.N

The drugmaker plans to raise U.S. investments by 25%, totaling $55 billion, over the next four years. It plans to build four plants, including one at Wilson, North Carolina, and another at Tokyo-based Fujifilm Biotechnologies' manufacturing site in Holly Springs, North Carolina, over the next 10 years.

Locations for the other plants remain undisclosed.

Roche ROG.S

The Swiss drugmaker said in April it will invest $50 billion in the U.S. over the next five years.

A month later, it announced an additional $550 million investment to expand its Indianapolis diagnostics manufacturing hub. The expansion will span Indiana, Pennsylvania, Massachusetts, and California, creating more than 12,000 jobs.

Roche said in May it plans to invest more than $700 million in a new drug manufacturing facility in Holly Springs, North Carolina.

CEO Thomas Schinecker said in July the company had moved around inventories and ramped up production of all the medicines that it already produced in the U.S. in anticipation of tariffs.

AstraZeneca AZN.L

The Anglo-Swedish drugmaker will invest $50 billion on U.S. manufacturing by 2030. The investment will fund a new drug substance facility in Virginia, its largest single-site global investment, alongside expansions in Maryland, Massachusetts, California, Indiana and Texas.

It has already started technology transfers and is managing inventory in 2025 to minimize any tariff hit. Company executives have said the impact would be "very short-lived."

Novartis NOVN.S

The Swiss drugmaker plans to spend $23 billion to build and expand 10 facilities in the U.S. over the next five years. This includes building six new manufacturing plants and expanding its San Diego research and development site, which is expected to create more than 1,000 jobs.

Sanofi SASY.PA

The French drugmaker plans to invest at least $20 billion in the U.S. through 2030 to boost manufacturing and research. Sanofi plans to expand its U.S. manufacturing capacity through direct investments in the company's sites and partnerships with other domestic manufacturers.

Chief Financial Officer François Roger said in July the potential tariffs are expected to have a limited impact in 2025, as the company already has inventory in place in the U.S.

Biogen BIIB.O

The U.S. drugmaker will invest $2 billion more in its existing manufacturing plants in North Carolina, adding capacity for gene-targeting therapies and automation. The company has seven factories in the state, with an eighth set to begin operations in late 2025.

Merck MRK.N

The U.S. drugmaker will invest $1 billion in a new Delaware plant to make biologics and Keytruda, to boost U.S. production and potentially create over 4,500 jobs. It also opened a $1-billion facility at its North Carolina site in March.

Its animal health unit will invest $895 million to expand its Kansas manufacturing and R&D site, part of a broader $9 billion U.S. investment through 2028.

CEO Robert Davis in July flagged minimal impact from potential tariffs in 2025, and that the company remained well-positioned due to inventory management and moving of manufacturing to the U.S.

Amgen AMGN.O

The U.S.-based biopharma firm plans to invest $900 million to expand its Ohio manufacturing facility, bringing total investment in the state to $1.4 billion and adding 750 jobs. In December, the company committed $1 billion to build a second facility in Holly Springs, North Carolina.

Amgen said in September it is investing more than $600 million to build a new research and development center at its headquarters in Thousand Oaks, California.

The drugmaker announced it will invest $650 million to expand drug manufacturing at its facility in Juncos, Puerto Rico, a move expected to create nearly 750 jobs.

Pfizer PFE.N

Earlier this year, the U.S. drugmaker said it had enough manufacturing capacity across its 10 U.S. sites and two distribution centers to manage potential tariff impacts and would consider shifting production to those facilities if needed.

Novo Nordisk NOVOb.CO

The Danish pharmaceutical company said in August its strong U.S. manufacturing footprint positions it well for tariff challenges, describing itself as "very U.S.-centric and U.S.-focused".

AbbVie ABBV.N

The U.S. drugmaker has confirmed plans to continue investing in its previously announced $10 billion expansion in the country over the next decade.

It already has 11 manufacturing sites in the U.S. and has said it is "fairly insulated" from any tariff impact this year given inventory management actions.

Gilead Sciences GILD.O

Earlier this year, the drugmaker announced $11 billion in new planned investment in the U.S. to add to its domestic manufacturing and research heft, taking its total pledged investment to $32 billion.

Gilead said in September that it started work on a pharmaceutical development and manufacturing hub at its headquarters in Foster City, California, in addition to which, it is currently developing two other sites.

Cipla CIPL.NS

The Indian drugmaker is expanding its U.S. manufacturing footprint by investing in capacity expansion for complex respiratory products at its advanced facilities in Fall River, Massachusetts, and Central Islip, Long Island, New York.

(Reporting by Siddhi Mahatole, Kamal Choudhury and Puyaan Singh in Bengaluru; Editing by Devika Syamnath and Leroy Leo)

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By Rishika Sadam and Jennifer Rigby

Sept 24 (Reuters) - Indian drugmakers Dr Reddy's Laboratories REDY.NS and Hetero Labs said on Wednesday that they will sell generic versions of a new and highly effective HIV prevention drug for roughly $40 per year beginning in 2027.

Lenacapavir, developed by Gilead Sciences GILD.O and approved earlier this year for HIV prevention under the brand name Yeztugo, is a twice-yearly injection that was nearly 100% effective at preventing HIV in large trials.

Some AIDS experts, including activists and doctors, say it could help control the 44-year-long epidemic that still infects 1.3 million people a year, and which the World Health Organization estimates has killed 44 million.

ENABLING BROADER ACCESS

The price tag, which will enable much broader access in low-and middle-income countries, compares with an estimated U.S. price of around $28,000 a year for branded Yeztugo.

Unitaid, a WHO-hosted global health agency that works on bringing new tools and medicines to countries more cheaply, is providing technical and financial support to Dr Reddy's for the low-cost effort, alongside the Clinton Health Access Initiative and South Africa's Wits Reproductive Health and HIV Institute (Wits RHI), part of University of the Witwatersrand.

The Gates Foundation is working with Hetero.

"Generic manufacture of lenacapavir is essential to ensure this breakthrough HIV prevention option is not limited to a privileged few," said Professor Saiqa Mullick, director of implementation science at Wits RHI.

The generic version with its low price point could be a preferred choice by millions affected in low-income countries, Mullick said.

The two manufacturers are among six Gilead granted royalty-free licenses to last year, to produce and sell the drug in 120 low- and lower-middle income countries with the highest global HIV disease burden by 2027, subject to approvals.

"The ($40) price that we have negotiated... brings the product in parity with the cost of the oral PrEP," Carmen Perez Casas, Unitaid's strategic lead for HIV, told Reuters, using the short phrase for pre-exposure prophylaxis, or preventive, drugs.

Injections at six-month intervals could benefit people for whom stigma, logistics, and other barriers make it difficult to take a pill every day, she added.

CHEAP GENERICS NEEDED FOR LONG-TERM DEMAND

U.S. biotech Gilead has faced criticism from patient advocacy groups and activists for not including upper-middle- income countries such as those in Latin America in the generics agreement.

"We are supporting organizations and countries to reflect on how we could overcome those access barriers (in excluded nations)," Casas said, noting that some countries, including Brazil, took part in trials of the medication but could not access the generics as the agreement with Gilead stands.

Gilead is already working with the Global Fund to Fight AIDS, Tuberculosis and Malaria and the U.S. government to get doses of its branded drug at a reduced price to 2 million people starting this year while generics ramp up production.

But experts estimate that long-term demand is likely to be closer to 10 million people or more, highlighting the need for cheaper generics at scale.

"The availability of generics at an affordable price... will magnify the impact of this game-changing innovation," Peter Sands, chief executive of the Global Fund, told Reuters.

($1 = 88.6930 Indian rupees)

(Reporting by Rishika Sadam in Bengaluru and Jennifer Rigby in New York; Editing by Bill Berkrot)

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Sept 22 (Reuters) - Dr Reddy's Laboratories Ltd REDY.NS:

• DR REDDY'S LABORATORIES LTD - RECEIVES POSITIVE CHMP OPINION FOR AVT03 BIOSIMILAR

• DR REDDY'S LABORATORIES LTD - HAS EXCLUSIVE U.S. RIGHTS FOR AVT03

Source text: ID:nBSE9Yk6hw

Further company coverage: REDY.NS

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Updates with GSK's investment plan

Sept 17 (Reuters) - Global drugmakers are scrambling to shore up their U.S. manufacturing capacity and domestic inventory as the Trump administration weighs hefty tariffs on pharmaceutical imports into the country.

Companies with more exposure to the UK, the EU, South Korea, and Japan are likely in a better position, as these countries have secured favorable agreements that cap tariffs at around 15%.

However, with many countries still engaged in trade talks with the U.S., businesses worldwide are hedging their decisions pending further clarity on final tariff rates.

Here's what drugmakers are doing to mitigate supply-chain risks and reassure investors:

GSK GSK.L

The London-based drugmaker plans to invest $30 billion in U.S. research and development and supply chain infrastructure over five years.

Eli Lilly LLY.N

The U.S. drugmaker said in September it will invest $5 billion to build a manufacturing facility in Virginia. The facility is the first of four new U.S. plants planned under its $27 billion expansion over the next five years.

Johnson & Johnson JNJ.N

The drugmaker plans to raise U.S. investments by 25%, totaling $55 billion, over the next four years. It plans to build four plants, including one at Wilson, North Carolina, and another at Tokyo-based Fujifilm Biotechnologies' manufacturing site in Holly Springs, North Carolina, over the next 10 years.

Locations for the other plants remain undisclosed.

Roche ROG.S

The Swiss drugmaker said in April it will invest $50 billion in the U.S. over the next five years.

A month later, it announced an additional $550 million investment to expand its Indianapolis diagnostics manufacturing hub. The expansion will span Indiana, Pennsylvania, Massachusetts, and California, creating more than 12,000 jobs.

Roche said in May it plans to invest more than $700 million in a new drug manufacturing facility in Holly Springs, North Carolina.

CEO Thomas Schinecker said in July the company had moved around inventories and ramped up production of all the medicines that it already produced in the U.S. in anticipation of tariffs.

AstraZeneca AZN.L

The Anglo-Swedish drugmaker will invest $50 billion on U.S. manufacturing by 2030. The investment will fund a new drug substance facility in Virginia, its largest single-site global investment, alongside expansions in Maryland, Massachusetts, California, Indiana and Texas.

It has already started technology transfers and is managing inventory in 2025 to minimize any tariff hit. Company executives have said the impact would be "very short-lived."

Novartis NOVN.S

The Swiss drugmaker plans to spend $23 billion to build and expand 10 facilities in the U.S. over the next five years. This includes building six new manufacturing plants and expanding its San Diego research and development site, which is expected to create more than 1,000 jobs.

Sanofi SASY.PA

The French drugmaker plans to invest at least $20 billion in the U.S. through 2030 to boost manufacturing and research. Sanofi plans to expand its U.S. manufacturing capacity through direct investments in the company's sites and partnerships with other domestic manufacturers.

Chief Financial Officer François Roger said in July the potential tariffs are expected to have a limited impact in 2025, as the company already has inventory in place in the U.S.

Biogen BIIB.O

The U.S. drugmaker will invest $2 billion more in its existing manufacturing plants in North Carolina, adding capacity for gene-targeting therapies and automation. The company has seven factories in the state, with an eighth set to begin operations in late 2025.

Merck MRK.N

The U.S. drugmaker will invest $1 billion in a new Delaware plant to make biologics and Keytruda, to boost U.S. production and potentially create over 4,500 jobs. It also opened a $1-billion facility at its North Carolina site in March.

Its animal health unit will invest $895 million to expand its Kansas manufacturing and R&D site, part of a broader $9 billion U.S. investment through 2028.

CEO Robert Davis in July flagged minimal impact from potential tariffs in 2025, and that the company remained well-positioned due to inventory management and moving of manufacturing to the U.S.

Amgen AMGN.O

The U.S.-based biopharma firm plans to invest $900 million to expand its Ohio manufacturing facility, bringing total investment in the state to $1.4 billion and adding 750 jobs. In December, the company committed $1 billion to build a second facility in Holly Springs, North Carolina.

Amgen said in September it is investing more than $600 million to build a new research and development center at its headquarters in Thousand Oaks, California.

Pfizer PFE.N

Earlier this year, the U.S. drugmaker said it had enough manufacturing capacity across its 10 U.S. sites and two distribution centers to manage potential tariff impacts and would consider shifting production to those facilities if needed.

Novo Nordisk NOVOb.CO

The Danish pharmaceutical company said in August its strong U.S. manufacturing footprint positions it well for tariff challenges, describing itself as "very U.S.-centric and U.S.-focused".

AbbVie ABBV.N

The U.S. drugmaker has confirmed plans to continue investing in its previously announced $10 billion expansion in the country over the next decade.

It already has 11 manufacturing sites in the U.S. and has said it is "fairly insulated" from any tariff impact this year given inventory management actions.

Gilead Sciences GILD.O

Earlier this year, the drugmaker announced $11 billion in new planned investment in the U.S. to add to its domestic manufacturing and research heft, taking its total pledged investment to $32 billion.

Gilead said in September that it started work on a pharmaceutical development and manufacturing hub at its headquarters in Foster City, California, in addition to which, it is currently developing two other sites.

Cipla CIPL.NS

The Indian drugmaker is expanding its U.S. manufacturing footprint by investing in capacity expansion for complex respiratory products at its advanced facilities in Fall River, Massachusetts, and Central Islip, Long Island, New York.

(Reporting by Siddhi Mahatole, Kamal Choudhury and Puyaan Singh in Bengaluru; Editing by Devika Syamnath and Leroy Leo)

(([email protected];))

Sept 16 (Reuters) - Dr Reddy's Laboratories Ltd REDY.NS:

• LAUNCHES NOVEL MOLECULE 'TEGOPRAZAN' IN INDIA

Further company coverage: REDY.NS

(([email protected];;))

Sept 3 (Reuters) - Global drugmakers are scrambling to shore up their U.S. manufacturing capacity and domestic inventory as the Trump administration weighs hefty tariffs on pharmaceutical imports into the country.

Companies with more exposure to the UK, the EU, South Korea and Japan are likely on better footing as these countries have secured favorable agreements capping tariffs at around 15%.

But with many countries still engaged in trade talks with the U.S., businesses around the world are hedging their decisions pending more clarity on final tariff rates.

Here's what drugmakers are doing to mitigate supply-chain risks and reassure investors:

Eli Lilly LLY.N

The U.S. drugmaker plans to invest $27 billion to build four new manufacturing facilities over the next five years in the U.S. It aims to announce two of its new site locations this quarter.

Johnson & Johnson JNJ.N

The drugmaker plans to raise U.S. investments by 25%, totaling $55 billion, over the next four years. It plans to build four plants, including one at Wilson, North Carolina, and another at Tokyo-based Fujifilm Biotechnologies' manufacturing site in Holly Springs, North Carolina, over the next 10 years.

Locations for the other plants remain undisclosed.

Roche ROG.S

The Swiss drugmaker said in April it will invest $50 billion in the U.S. over the next five years.

A month later, it announced an additional $550 million investment to expand its Indianapolis diagnostics manufacturing hub. The expansion will span Indiana, Pennsylvania, Massachusetts, and California, creating more than 12,000 jobs.

Roche said in May it plans to invest more than $700 million in a new drug manufacturing facility in Holly Springs, North Carolina.

CEO Thomas Schinecker said in July the company had moved around inventories and ramped up production of all the medicines that it already produced in the U.S. in anticipation of tariffs.

AstraZeneca AZN.L

The Anglo-Swedish drugmaker will invest $50 billion on U.S. manufacturing by 2030. The investment will fund a new drug substance facility in Virginia, its largest single-site global investment, alongside expansions in Maryland, Massachusetts, California, Indiana and Texas.

It has already started technology transfers and is managing inventory in 2025 to minimize any tariff hit. Company executives have said the impact would be "very short-lived."

Novartis NOVN.S

The Swiss drugmaker plans to spend $23 billion to build and expand 10 facilities in the U.S. over the next five years. This includes building six new manufacturing plants and expanding its San Diego research and development site, which is expected to create more than 1,000 jobs.

Sanofi SASY.PA

The French drugmaker plans to invest at least $20 billion in the U.S. through 2030 to boost manufacturing and research. Sanofi plans to expand its U.S. manufacturing capacity through direct investments in the company's sites and partnerships with other domestic manufacturers.

Chief Financial Officer François Roger said in July the potential tariffs are expected to have a limited impact in 2025, as the company already has inventory in place in the U.S.

Biogen BIIB.O

The U.S. drugmaker will invest $2 billion more in its existing manufacturing plants in North Carolina, adding capacity for gene-targeting therapies and automation. The company has seven factories in the state, with an eighth set to begin operations in late 2025.

Merck MRK.N

The U.S. drugmaker will invest $1 billion in a new Delaware plant to make biologics and Keytruda, to boost U.S. production and potentially create over 4,500 jobs. It also opened a $1-billion facility at its North Carolina site in March.

Its animal health unit will invest $895 million to expand its Kansas manufacturing and R&D site, part of a broader $9 billion U.S. investment through 2028.

CEO Robert Davis in July flagged minimal impact from potential tariffs in 2025, and that the company remained well-positioned due to inventory management and moving of manufacturing to the U.S.

Amgen AMGN.O

The U.S.-based biopharma firm plans to invest $900 million to expand its Ohio manufacturing facility, bringing total investment in the state to $1.4 billion and adding 750 jobs. In December, the company committed $1 billion to build a second facility in Holly Springs, North Carolina.

Amgen said in September it is investing more than $600 million to build a new research and development center at its headquarters in Thousand Oaks, California.

Pfizer PFE.N

Earlier this year, the U.S. drugmaker said it had enough manufacturing capacity across its 10 U.S. sites and two distribution centers to manage potential tariff impacts and would consider shifting production to those facilities if needed.

Novo Nordisk NOVOb.CO

The Danish pharmaceutical company said in August its strong U.S. manufacturing footprint positions it well for tariff challenges, describing itself as "very U.S.-centric and U.S.-focused".

AbbVie ABBV.N

The U.S. drugmaker has confirmed plans to continue investing in its previously announced $10 billion expansion in the country over the next decade.

It already has 11 manufacturing sites in the U.S. and has said it is "fairly insulated" from any tariff impact this year given inventory management actions.

Gilead Sciences GILD.O

Earlier this year, the drugmaker announced $11 billion in new planned investment in the U.S. to add to its domestic manufacturing and research heft, taking its total pledged investment to $32 billion.

Gilead said in September that it started work on a pharmaceutical development and manufacturing hub at its headquarters in Foster City, California, in addition to which, it is currently developing two other sites.

Cipla CIPL.NS

The Indian drugmaker is expanding its U.S. manufacturing footprint by investing in capacity expansion for complex respiratory products at its advanced facilities in Fall River, Massachusetts, and Central Islip, Long Island, New York.

(Reporting by Siddhi Mahatole, Kamal Choudhury and Puyaan Singh in Bengaluru; Editing by Devika Syamnath and Leroy Leo)

(([email protected];))